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3 Mounjaro and Wegovy typically raise resting heart rate by 2 to 4 bpm, so retatrutides increase is roughly two to three times larger

It is worth noting that tirzepatide's mechanism of slowing gastric emptying could theoretically exacerbate reflux symptoms in susceptible individuals, and acid reflux can occasionally cause throat irritation

A provider that skips titration steps or starts you at a high dose is cutting corners that could result in severe gastrointestinal side effects , persistent fatigue , or worse

What are some of the boxes that we should check off that we're not missing certain medical conditions

The FDA determined the tirzepatide shortage resolved in late 2024 and the semaglutide shortage resolved in February 2025, and it set enforcement deadlines through 2025 for compounders to wind down shortage-based production